Table 5. Analyses of combined alleles of PTPN22 and CTLA4 genes, haplotypes and genotypes of -550 and -221 promoter region and exon 1 of MBL2 gene in TS patients and controls.

PTPN22	CTLA4	Frequencies in TS	Frequencies in controls	p-value	OR (95% C.I.)
G	A	0.6512	0.5697	Reference	1.00
G	G	0.3372	0.3939	0.16	0.76 (0.52-1.11)
A	A	0.0116	0.027	0.25	0.39 (0.08 - 1.93)
A	G	0	0.0093	1	0.00 (-Inf - Inf)
Global haplotype association p-value: 0.14
MBL producers and haplotype		Frequencies in TS	Frequencies in controls	p-value	OR (95% C.I.)
High MBL producers
LYA		0.3827	0.4272	Reference	1.00
HYA		0.2586	0.2694	0.89	1.04 (0.62 1.73)
Low MBL producers
LXA		0.1453	0.1467	0.69	1.12 (0.64 1.94)
Deficient MBL producers
LYO		0.1464	0.0861	0.13	1.75 (0.85 3.60)
HYO		0.0669	0.0706	0.84	1.10 (0.45 2.67)
Global haplotype association p-value: 0.63
MBL producers and genotypes		TS group (n = 65)	Control (n = 150)	p-value	OR (95%C.I.)
High MBL producers
HYA/HYA
HYA/LYA		27 (0.42)	76 (0.51)	Reference	Reference
LYA/LYA
Low MBL producers
LXA/LXA
LYA/LXA
HYA/LXA
HYA/HYO		32 (0.49)	63 (0.42)	0.278	1.42(0.74-2.76)
HYA/LYO
LYA/LYO
Deficient MBL producers
HYO/LXA
HYO/LYO
LYO/LXA		6 (0.09)	11 (0.07)	0.558	1.53(0.42-5.06)
LYO/LYO
HYO/HYO