Table 3.
Independent predictors of hs-cTnI concentration greater than recommended ULN in final study population (n=18 171)
| Variable | Predictors of manufacturer troponin ULN >40 ng/L | Predictors of non-parametric troponin ULN >189 ng/L | |||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | ||
| Age (per year increase) | 1.03 (1.03 to 1.04) | <0.001 | 1.03 (1.02 to 1.04) | <0.001 | |
| Male sex | 1.33 (1.14 to 1.54) | <0.001 | 0.90 (0.66 to 123) | 0.51 | |
| Sodium (per unit increase) | 0.99 (0.97 to 1.01) | 0.34 | 1.01 (0.97 to 1.04) | 0.74 | |
| eGFR (per unit increase) | 0.98 (0.97 to 0.98) | <0.001 | 0.99 (0.98 to 1.00) | 0.001 | |
| Inpatient location v outpatient | |||||
| Emergency department | 2.79 (2.26 to 3.43) | <0.001 | 3.46 (2.14 to 5.61) | <0.001 | |
| Resuscitation room | 9.91 (7.3 to 13.46) | <0.001 | 13.79 (7.67 to 24.77) | <0.001 | |
| Critical care units | 36.62 (23.86 to 56.2) | <0.001 | 99.27 (55.51 to 177.54) | <0.001 | |
| Cardiac wards | 9.08 (6.44 to 12.81) | <0.001 | 14.91 (7.91 to 28.11) | <0.001 | |
| Acute surgical unit | 2.52 (1.47 to 4.33) | 0.001 | 0.98 (0.13 to 7.21) | 0.98 | |
| Medical wards | 4.74 (3.45 to 6.50) | <0.001 | 5.80 (2.95 to 11.42) | <0.001 | |
| Medicine for older people wards | 3.70 (2.16 to 6.34) | <0.001 | 9.60 (4.00 to 23.00) | <0.001 | |
| Orthopaedic wards | 2.24 (1.23 to 4.05) | 0.008 | 2.15 (0.51 to 9.14) | 0.30 | |
eGFR=estimated glomerular filtration rate; hs-cTnI=high sensitivity cardiac troponin I; ULN=upper limit of normal (40 ng/L).