Table 1.
Distribution of ovarian cancer histopathology by tumor marker in the Nurses’ Health Studies and the New England Case Control Study
| COX1* | COX2† | CD163‡ | CD68‡ | |||||
|---|---|---|---|---|---|---|---|---|
| − | + | − | + | low | high | low | high | |
| Total, n | 378 | 154 | 353 | 179 | 212 | 318 | 183 | 347 |
| Histology, (%) | ||||||||
| Serous | 65.1 | 83.8 | 70.0 | 71.5 | 53.8 | 82.1 | 60.1 | 76.4 |
| Mucinous | 5.3 | 0.0 | 1.7 | 7.8 | 9.0 | 0.9 | 8.7 | 1.7 |
| Endometrioid | 17.5 | 7.1 | 15.6 | 12.3 | 20.8 | 9.1 | 16.4 | 12.4 |
| Clear cell | 7.1 | 6.5 | 8.5 | 3.9 | 11.3 | 4.1 | 9.8 | 5.5 |
| Other | 5.0 | 2.6 | 4.2 | 4.5 | 5.2 | 3.8 | 4.9 | 4.0 |
| Grade, (%) | ||||||||
| Borderline | 12.4 | 7.1 | 9.9 | 12.8 | 23.1 | 3.5 | 23.0 | 5.2 |
| 1 | 9.5 | 3.9 | 7.9 | 7.8 | 13.2 | 4.7 | 13.1 | 5.5 |
| 2 | 6.1 | 2.6 | 4.8 | 5.6 | 8.0 | 2.8 | 6.0 | 4.3 |
| 3 | 70.1 | 85.1 | 76.2 | 70.9 | 53.8 | 86.8 | 57.4 | 82.1 |
| Unknown | 1.9 | 1.3 | 1.1 | 2.8 | 1.9 | 2.2 | 0.5 | 2.9 |
| Stage, (%) | ||||||||
| 1 | 29.1 | 19.5 | 24.4 | 30.2 | 40.1 | 17.0 | 36.6 | 20.7 |
| 2 | 9.8 | 4.5 | 9.6 | 5.6 | 9.9 | 6.9 | 7.7 | 8.4 |
| 3 | 51.1 | 63.6 | 55.5 | 53.1 | 40.6 | 64.8 | 45.4 | 60.2 |
| 4 | 4.0 | 3.9 | 4.0 | 3.9 | 2.4 | 5.0 | 2.7 | 4.6 |
| Unknown | 6.1 | 8.4 | 6.5 | 7.3 | 7.1 | 6.3 | 7.7 | 6.1 |
*
Tumors were classified as COX1- when there was no evidence of staining or only weak intensity staining, and COX1+ when there was moderate to high intensity staining in ≥10% of cells.
†
Tumors were classified as COX2- when <5% of cells stained, and COX2+ when there was staining in ≥5% of cells.
‡
CD68 and CD163 were scored as low when <10% of cells stained and staining was scattered. CD68 and CD163 were scored as high when <10% of cells stained, with aggregation, or when ≥10% of cells stained.