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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: ChemMedChem. 2018 Jul 31;13(17):1779–1796. doi: 10.1002/cmdc.201800332

Figure 2.

Figure 2.

Overview of the structure activity relationship studies of adefovir (PMEA) analogues as ACT inhibitors. Blue colour depicts the positions on the purine scaffold modified in this work, namely positions C-1, C-3, C-7, C-8, and C-9.