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Synthesis of compounds 18a and 18b. Reagents and conditions: i) NaH, DMF, 80 °C, then Cl(CH2)2OCH2P(O)(OiPr)2, DMF, 100 °C; ii) Cl(CH2)2OCH2P(O)(OiPr)2, DBU, DMF, 100 °C; iii) TMSBr, pyridine, rt; then (L)-NH2CH(Bn)COOiPr·HCl, PPh3, Aldrithiol-2, pyridine, Et3N, 70 °C.
