. Author manuscript; available in PMC: 2019 Sep 6.

Published in final edited form as: ChemMedChem. 2018 Jul 31;13(17):1779–1796. doi: 10.1002/cmdc.201800332

Table 4.

IC₅₀ values and % activity on AC1 and AC2 in HEK293 cells.

Compound	AC1		AC2

	% Response^[a]	IC₅₀ (µM)^[b]	% Response	IC_{50 (}µM)
6c	22 ±5	5.6 ±1.7	143 ±21	ND^[c]
6d	22 ±4	4.3 ±0.5	142 ±11	ND
6e	25 ±4	4.1 ±1.1	177 ±3	ND
SKF83566	ND	ND	14 ±5	5.0 ±1.6

^[a]

Percentages shown correspond to % mAC activity at 30 μM inhibitor normalized to the control response (no inhibitor). Values greater than 100% represent a potentiated response.

^[b]

Values are shown as mean and SEM of three independent experiments.

^[c]

ND, not determined.