Table 3.

Univariate and multivariate analyses of prognostic factors in ESCC patients

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Sex (female/male)	0.537 (0.274–1.054)	0.071	–	–
Age (<60/≥60 years)	0.651 (0.353–1.203)	0.171	–	–
Tumor size (<5 cm/≥5 cm)	2.277 (1.114–4.653)	0.024	3.662 (1.642–8.166)	0.002
Histological differentiation (good/moderate/poor)	2.149 (1.261–3.663)	0.005	1.429 (0.795–2.571)	0.233
Tumor invasion (Tis–T1/T2–T4)	3.415 (1.216–9.597)	0.020	1.643 (0.556–4.856)	0.369
Lymph-node metastasis (present/absent)	5.364 (2.837–10.142)	<0.001	4.238 (2.164–8.300)	<0.001
TNM stage (0–I/II–III)*	2.688 (1.129–6.400)	0.025	–	–
Ki67 expression (low vs high)	2.122 (1.012–4.448)	0.046	0.899 (0.401–2.015)	0.899
MYBL2 expression (low vs high)	5.513 (1.960–15.503)	0.001	5.977 (1.770–20.185)	0.004

Note:

^*Not included in multivariate analysis, because this variable is a confounding factor of tumor invasion and lymph-node metastasis.

Abbreviation: ESCC, esophageal squamous-cell carcinoma.