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. 2018 Jul 20;315(5):H1101–H1111. doi: 10.1152/ajpheart.00209.2018

Fig. 3.

Fig. 3.

Membrane capacitance and Ca2+ current (ICa). A: cell capacitance (in pF) of intact and detubulated (DT) myocytes used for electrophysiology from wild-type (WT) mice [intact n cells/N hearts (n/N): 35/13 and DT n/N = 38/13] and caveolin-3 (Cav-3) knockout (KO) mice (intact n/N: 39/17 and DT n/N: 43/14). B: exemplar records of ICa recorded at 0 mV from intact and DT WT and Cav-3 KO myocytes. C and D: mean ICa density-voltage relations from intact (C; WT n/N = 24/7 and Cav-3 KO n/N = 26/11) and DT (D; WT n/N = 28/9 and Cav-3 KO n/N = 31/9) WT and Cav-3 KO myocytes. E and F: mean ICa density (E) and absolute ICa (F) at 0 mV in intact and DT (“surface”) cells and calculated at the t-tubule membrane (“t-tubule”) for WT (open columns) and Cav-3 KO (solid columns) myocytes. *P < 0.05; **P < 0.01; ***P < 0.001.