Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 24;562(7728):583–588. doi: 10.1038/s41586-018-0617-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Springer Nature Limited 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 4 — Data are based on 16S rRNA gene sequencing (n = 11,717). Analysis based on a nested 1:1 case–control cohort of equal samples. Curves show LOESS fit for the data per category, and shaded areas show permutation-based 95% confidence intervals for the fit. a, b, The number of OTUs (a) and the Shannon’s diversity index (b) in the IA cohort. c, d, The number of OTUs (c) and Shannon’s diversity (d) in the T1D cohort. e, f, Microbiota age (e) and MAZ score (f) in the IA cohort. g, h, Microbiota age (g) and MAZ score (h) in the T1D cohort. i, j, Forest plot showing the odds ratios for the association between the microbiome stability metrics and development of IA (i) and T1D (j). A separate conditional logistic regression was run for four time intervals: (1) birth to onset; (2) 12 months before onset; (3) 6–12 months before onset; and (4) 6 months before onset. Models were adjusted for HLA genotype, mode of delivery, duration of exclusive breastfeeding, number of antibiotic courses, and number of infectious episodes. Community states are the total number of unique clusters exhibited by an infant and state transitions are the number of transitions between clusters. No odds ratio was significantly different between cases and controls (Supplementary Table 3).