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. Author manuscript; available in PMC: 2019 Dec 12.
Published in final edited form as: Clin Sci (Lond). 2018 Dec 5;132(23):2519–2545. doi: 10.1042/CS20180623

Figure 1. Release of obstruction significantly resolves the renal damage due to obstruction:

Figure 1.

(A) Partial ureteral obstruction was created in left kidneys of newborn mice within the first 48h after birth. The obstruction was released at 1 week for some of them. Tissues were collected at 1, 3 and 8 WO and 1, 2 and 7 WR. (B) In some of the animals partial ureteral obstruction even for 1 week (W) resulted in severe hydronephrotic, fluid filled kidneys (black arrow). With persistent ipsilateral ureteral obstruction, the kidneys deteriorated and degenerated further leading to arrested growth and atrophy (arrow head). By contrast, relief of obstruction at seven days resulted in decreased hydronephrosis and remarkable kidney remodeling (yellow arrow). Scale bars, 2mm. (C) To assess the extent of obstruction injury, kidneys were scored for the severity of hydronephrosis at the time of release and tissue harvest in a scale of 1–4. Score1-Kidneys normal in appearance; 2-Kidneys appear hydronephrotic (i.e. distended), but without obvious translucent areas; 3-Kidneys are distended with obvious translucent areas, but retain significant remaining parenchyma; 4-Very severe hydronephrosis with little if any remaining parenchyma [5]. Scale bars, 1mm.