Figure 10. Expansion of PDGFRβ positive cells during obstruction injury:
(A) Immunostaining for PDGFRβ showed an increase in pericyte expansion (black arrows) in obstructed kidneys compared to sham-operated kidneys (black arrows). PDGFRβ status at 2 weeks post-release was similar to sham kidneys (black arrows). Scale bars, 50μm. (B) Quantification of PDGFRβ positive area in tissue sections confirmed a significant increase in obstructed kidneys (n=3) in comparison with sham-operated kidneys (n=3). Release of obstruction (n=3) showed a similar pattern of PDGFRβ stained area as observed in the sham kidneys (***P<0.001; NS-non significant).