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. Author manuscript; available in PMC: 2019 Dec 12.
Published in final edited form as: Clin Sci (Lond). 2018 Dec 5;132(23):2519–2545. doi: 10.1042/CS20180623

Figure 4. Relief of obstruction ameliorates obstructive vascular damage:

Figure 4.

Analyses of (A) afferent arterioles and (B) other renal arterioles in toluidine blue stained semi-thin sections showed intact vascular smooth muscle cell (SMC) lining of the arterioles in sham-operated kidneys (yellow arrows). On the other hand, kidneys obstructed for 3 weeks showed an extensive degeneration of the vessels including thinning of SMCs in the arteriolar walls (red arrows) as well as loss of endothelial cells (green arrows). In addition, pericytes detached from the capillary wall and several pericyte-like cells were seen loose in the interstitial space (black arrows) with excessive deposition of interstitial matrix. Release of obstruction at 7 days resulted in the restoration of arteriolar SMC architecture (yellow arrows) and regeneration of the vasculature. Scale bars, 10μm.