Figure 7. Reduction of renal oxidative stress following the release of obstruction.
(A) Immunostaining for Heme oxygenase-1(HO-1) on kidney sections from sham, 3W obstructed and 2W post-release showing increased expression of HO-1 in interstitial cells of both cortical and medullary regions from 3W obstructed kidneys (black arrows, arrow heads in enlarged insets). Scale bars, 50μm. (B) Immunostaining for 4-hydroxynonenal (4-HNE) showing positive cells in 3W obstructed kidneys (arrows) whereas sham and released kidneys of similar age groups were negative for 4-HNE. (Scale bars, 50 μm, 10 μm)