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. 2019 Mar 13;15(3):e1008011. doi: 10.1371/journal.pgen.1008011

Fig 4. Methylcobalamin supplementation improves host resistance.

Fig 4

(A-B) Representative images and quantification of survival of glp-4 (bn2) C. elegans exposed to P. aeruginosa PA14 after feeding on OP50 with or without methylcobalamin (B12) supplementation. (C-F) Effect of feeding on E. coli OP50 supplemented with methylcobalamin on C. elegans resistance to phenanthroline (C), infection with E. faecalis (D), peroxide exposure (E), CCCP poisoning (F), or hyperthermia (G), or lifespan (F). p-value for (E) <0.01; (F) > 0.05 (N.S). p-values were calculated using log-rank test (E, F) or Student’s t-test (B-D). *—p<0.01. For (A, B, D, E, F), 10 wells, each containing 20 worms, were used for each diet for each replicate. For (C, G, H), 50 worms were used per plate, three plates per replicate per condition. Three biological replicates were performed for each experiment.