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Summary of the contrasting effects of selected rates of stimulation/voltage clamp-induced activation on Ca2+-independent transient outward K+ current (Ito) in the human atrium models in which Ito is generated by only Kv4.3 (A), only Kv1.4 (B), and a 50:50 mixture of Kv4.3 and Kv1.4 (C) while ensuring that Ito conductance remained constant. In all simulations, the holding potential was −60 mV, and each Ito record was elicited by a 200-ms rectangular voltage clamp step to 0 mV.
