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. 2019 Mar 13;14(3):e0213622. doi: 10.1371/journal.pone.0213622

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© 2019 Santamaria-Martos et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — Patients who were referred because of suspected OSA were divided into the TLDA cohort (general profile of miRNAs) and the validation cohort and further divided for study on the basis of non-OSA and OSA. Ten non-OSA and 30 OSA patients were used as the TLDA cohort. miRNAs that do not follow the characteristics of a good EC were excluded. Two different strategies (mean-center+SD and CCR) were used in order to select candidate ECs. Stability analysis by GeNorm and NorFinder was performed in the TLDA cohort and in an independent validation cohort (20 non-OSA and 40 OSA patients).