Figure 1:

Overview of the automatically annotated fiber cluster (AAFC) method. Given the diffusion MRI dataset (a) of each subject, whole-brain tractography (b) is performed. Next, data-driven groupwise whole brain fiber clustering is performed to produce a fiber cluster atlas (c) across multiple subjects, which is applied to obtain fiber clusters (e) (black fibers show one example cluster from the cluster atlas (d)) in each individual subject. Then, a parcellation-based cluster identification (PBCI) is performed using each subject’s cortical parcellation to identify fibers belonging to known tracts (e.g. the blue fibers in (f) belong to the corticospinal tract (CST)). Finally, an annotating strategy for each fiber cluster across subjects is performed to label all fiber clusters belonging to CST (g).