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. Author manuscript; available in PMC: 2019 Mar 13.
Published in final edited form as: ACS Catal. 2018 Oct 31;8(12):11722–11734. doi: 10.1021/acscatal.8b03171

Figure 5.

Figure 5.

Influence of carbon flux on FAS outputs. (A) Total production and average length of fatty acids generated by modeled FASs (1 μM of each Fab, 10 μM TesA, 10 μM holo-ACP, 1 mM NADPH, 1 mM NADH, and 0.5 mM acetyl-CoA, 12.5 min) with varying concentrations of malonyl-CoA. As concentrations of malonyl-CoA increase, production levels increase gradually, while average length increases abruptly over a narrow range of concentrations. (B) Enhanced production levels correlate with an increase in initiation events; average chain length, with an increase in the ratio of elongation to initiation events (i.e., the relative activities of FabF and FabH on malonyl-ACP).