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. 2019 Feb 25;132(5):577–588. doi: 10.1097/CM9.0000000000000108

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Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Network map of the clinical efficacy and safety of aprotinin, EACA, TXA1, and TXA2. (A) Intraoperative blood loss, (B) postoperative blood loss, (C) total blood loss, (D) blood transfusion, (E) ratios of blood transfusion, (F) operative time, (G) postoperative Hb value, (H) postoperative Hct value, (I) incidence of DVT, (J) incidence of PE. Node size and line width are based on the number of intervention studies included in the meta-analysis. Larger nodes and thicker lines indicate a higher frequency of intervention with the indicated drug. DVT: Deep vein thrombosis; EACA: Epsilon-aminocaproic acid; Hb: Hemoglobin; Hct: Hematocrit; PE: Pulmonary embolism; TXA1: Low dose of tranexamic acid; TXA2: High dose of tranexamic acid.