1.24. Analysis.
Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 24 Sperm concentration at 3 months or less (data not suitable for meta analysis).
| Sperm concentration at 3 months or less (data not suitable for meta analysis) | |||
|---|---|---|---|
| Study | Intervention | Control | P value |
| Carnitines | |||
| Cavallini 2004 |
L‐carnitine + Acetyl‐carnitine Median = 20.9 (n = 39) Interquartile range = 25.6 ‐ 14.8 |
Placebo Median = 12.3 (n = 47) Interquartile range = 16.0 ‐ 9.1 |
Not provided |
| Lenzi 2003 |
L‐carnitine Mean = 9 (1st phase data) (n = 43) No SD given |
Placebo Mean = 5.3 (n = 43) No SD given |
P = 0.03 |
| Vitamin E | |||
| Kessopoulou 1995 |
Vitamin E Median = ‐15 (n = 15) Min/max = ‐58 ‐ 59 |
Placebo Median = 0 (n = 15) Min/max = ‐37 ‐ 160 |
Not provided |
| Folic acid | |||
| Raigani 2014 |
Folic acid Median 15 (9.7 ‐ 24) (n = 20) Median (25th ‐ 75th percentile) 16 weeks |
Placebo Median 12 (7.5 ‐ 27.3) Median (25th ‐ 75th percentile) 16 weeks |
Not provided |
| Zinc | |||
| Raigani 2014 |
Zinc Median 13.2 (7 ‐ 27) (n = 24) Median (25th ‐ 75th percentile) 16 weeks |
Placebo Median 12 (7.5 ‐ 27.3) Median (25th ‐ 75th percentile) 16 weeks |
Not provided |
| Folic acid + Zinc | |||
| Raigani 2014 |
Folic acid + Zinc Median 10.5 (8.06 ‐ 17.7) (n = 21) Median (25th ‐ 75th percentile) 16 weeks |
Placebo Median 12 (7.5 ‐ 27.3) Median (25th ‐ 75th percentile) 16 weeks |
Not provided |
| Combined antioxidants | |||
| Gamidov 2017 |
SpermActin‐forte (acetyl‐L‐carnitine, L‐carnitine fumarate and alpha‐lipoic acid) Median = 26.5 (2.3 ‐ 48) Median (interquartile range) |
No treatment Median = 22 (11.5 ‐ 26.6) Median (interquartile range) |
Not provided |
| Gamidov 2017 |
SpermActin‐forte + Vitamin complex 'Man's formula' Median = 23.5 (10 ‐34.5) (n = 38) Median (interquartile range) |
No treatment Median = 22 (11.5 ‐ 26.6) (n = 38) Median (interquartile range) |
Not provided |