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. 2019 Mar 14;2019(3):CD007411. doi: 10.1002/14651858.CD007411.pub4
Date Event Description
4 December 2018 New search has been performed Nineteen new studies were added in this update (Barekat 2016; Blomberg Jensen 2018; Boonyarangkul 2015; Busetto 2018; Cyrus 2015; Deng 2014; Ener 2016; Exposito 2016; Gamidov 2017; Gopinath 2013; Haghighian 2015; Haje 2015; Martinez 2015; Mehni 2014; Micic 2017; Pourmand 2014; Raigani 2014; Sharifzadeh 2016; Sofikitis 2016). There is one study placed in awaiting classification (Goswami 2015).
All pentoxifylline studies were excluded. Two previously included studies were excluded for containing an ineligible study population.
4 December 2018 New citation required and conclusions have changed Pentoxifylline was removed from the review due to the fact that it is a prescription drug and not an 'over‐the‐counter' supplement.
Progressive sperm motility was added as a secondary outcome; this is an outcome with more clinical importance than total sperm motility.