Peivandi 2010.
Methods | Randomised double‐blind cross‐over trial Duration of study: unclear, from 2005 to 2006 |
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Participants | Country: Iran Population: infertile men, N = 30 Mean age: 29.5 (SD 5.48) years Inclusion criteria: at least two abnormal spermograms based on WHO criteria with a two‐week interval during four weeks, normal range of gonadotropins, testosterone an prolactin concentrations Exclusion criteria: variocoele, testicular atrophy, ejaculatory disorders, use of medications, azoospermia, endocrinological disorders, ICSI candidacy or other causes of infertility |
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Interventions | L‐carnitine 2 g (n = 15) versus Placebo (n = 15) Duration of treatment: 8 weeks, washout period of 8 weeks, changed intervention and use for 8 more weeks |
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Outcomes | Sperm parameters | |
Notes | Abstract in English, full text in Arabic. Contacted the author and he is filling out the data extraction sheets. Author responded but data queries remain contacted again re SDs and pregnancies in first phase of cross‐over. Author responded saying that the data were given in SDs and there were 3 pregnancies in the first phase 2018: added data on progessive motility for first phase (2 months). |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not mentioned |
Allocation concealment (selection bias) | Low risk | Quote: "sealed opaque envelopes" |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Quote: "Double blind". Placebo used. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Quote: "outcome assessor was blinded" |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Quote: "loss to follow up was not accounted for" |
Selective reporting (reporting bias) | Unclear risk | Outcomes reported. No protocol available. |