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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Mol Psychiatry. 2018 Sep 13;24(5):710–725. doi: 10.1038/s41380-018-0245-8

Figure 5. Chemogenetic activation of Hoxb1-NE neurons results in significant decrease in CBV at stress-related targets.

Figure 5.

(a-f) CBV-weighted fMRI traces from the color-coded regions of interest depicted in representative coronal scans show decreased CBV in dorsal BNST (yellow), ventral BNST (purple), amygdala (green), hypothalamus (blue), and locus coeruleus (red) but no change in the caudate putamen (black) of Hoxb1-NE/hM3Dq mice following 1 mg/kg CNO administration (n=7–8). No change was observed in the controls (n=6). Error bars represent ± SEM. (g) Bar graph shows comparison of CBV-weighted fMRI signal changes between baseline (first 10 min) and post-CNO (final 20 min) in control and Hoxb1-NE/hM3Dq mice. *P< 0.05, **P<0.01, ***P<0.001, unpaired 2-tailed t-test. Data are displayed as mean ± SEM.