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. Author manuscript; available in PMC: 2019 Mar 14.
Published in final edited form as: Bioconjug Chem. 2018 Sep 28;29(10):3231–3239. doi: 10.1021/acs.bioconjchem.8b00592

Figure 2:

Figure 2:

Target bioanalyte binds active site (left) to form bioanalyte-enzyme complex (middle) where a catalytic reaction converts target bioanalyte to measurable reaction product (dark circle, right).