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. Author manuscript; available in PMC: 2019 Mar 14.
Published in final edited form as: Bioconjug Chem. 2018 Sep 28;29(10):3231–3239. doi: 10.1021/acs.bioconjchem.8b00592

Figure 5:

Figure 5:

Steric hinderances occur when antibody recognition elements are too closely packed resulting in a conformational change making binding sites inaccessible.