Figure 2.

miRNA regulation of osteoclast differentiation. Illustration of the 3 phases of osteoclastogenesis. The early phase is associated with pre-osteoclast (OC) survival, motility, and proliferation; the late phase focused on pre-OC cell fusion and OC acting-ring formation; and the mature OC phase consists in the degradation of the mineralized matrix by mature OC. Green, red and black colors indicate down, up and normal miRNA expression, respectively. Arrows and bars indicate positive or negative effects on osteoclastogenesis respectively. M-CSF, macrophage colony-stimulating factor; RANKL, Receptor activator of NF-κB ligand.