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. 2019 Mar 7;10:169. doi: 10.3389/fphar.2019.00169

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Copyright © 2019 Kutzner, Rund, Ostermann, Hartung, Galano, Balas, Durand, Balzer, David and Schebb.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration of selected lipid mediators measured in plasma from patients with (sepsis, n = 18) and without (control, n = 10) septic shock. Patients with septic shock are divided into survivors (>28 days, n = 5) and non-survivors (n = 13). Shown are concentrations in nM as individual values of (A) ARA derived PGE₂, 5-lipoxygenation products and SPM pathway marker as well as SPMs derived from (B) ARA, (C) EPA, and (D) DHA. Median is given, if >50% of the samples are >LLOQ. The LLOQ is indicated as dotted line.