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Pharmacokinetics of l-ornithine l-aspartate (LOLA) in patients with cirrhosis, hyperammonemia and hepatic encephalopathy. a Plasma levels of l-ornithine 4 h and 8 h post-infusion of 5–20 g LOLA versus placebo. b Plasma levels of l-aspartate 4 h and 8 h post-infusion of 5–40 g LOLA versus placebo. Intensity of shading indicates increasing doses of LOLA. Error bars indicate mean ± SEM; values significantly different from baseline (9 a.m. values) indicated by *p < 0.05, **p < 0.01 by ANOVA
