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. 2019 Mar 13;9:4329. doi: 10.1038/s41598-019-40437-5

Table 3.

Spearman’s correlation coefficients evaluating the relationship of each shape feature with tumor complexity.

M1 M2 M3
r (95% CI) p-value* r (95% CI) p-value* r (95% CI) p-value*
Surface Area −0.98 (−0.992–0.960) p < 10-4 −0.98 (−0.990–0.952) p < 10-4 −0.98 (−0.992–0.962) p < 10-4
Surface-to-Volume −0.98 (−0.992–0.960) p < 10-4 −0.98 (−0.990–0.952) p < 10-4 −0.98 (−0.992–0.962) p < 10-4
Compactness1 0.98 (0.960–0.991) p < 10-4 0.98 (0.952–0.990) p < 10-4 0.98 (0.961–0.992) p < 10-4
Compactness2 0.98 (0.960–0.991) p < 10-4 0.98 (0.952–0.990) p < 10-4 0.98 (0.961–0.992) p < 10-4
Compactness3 0.98 (0.960–0.991) p < 10-4 0.98 (0.952–0.990) p < 10-4 0.98 (0.961–0.992) p < 10-4
Spherical Disproportion −0.98 (−0.992–0.960) p < 10-4 −0.98 (−0.990–0.952) p < 10-4 −0.98 (−0.992–0.962) p < 10-4
Sphericity 0.98 (0.960–0.991) p < 10-4 0.98 (0.952 –0.990) p < 10-4 0.98 (0.961–0.992) p < 10-4
Fractional Concavity 0.94 (0.882–0.975) p < 10-4 0.83 (0.661–0.921) p < 10-4 0.96 (0.920–0.983) p < 10-4

*p-values: Surface Area, Surface-to-Volume, Compactness 1, Compactness 2, Compactness 3, Spherical Disproportion, Sphericity M1: 2.2.10-16, M2: 2.2.10-16, M3: 2.2.10-16, Fractional Concavity M1: 1.2.10-13, M2: 7.44.10-8, M3: 8.4.10-16.