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. 2018 Mar 26;6:7. doi: 10.1038/s41413-017-0003-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Femoral volume of interest is indicated. Representative femoral trabecular bone volumes of 36 wk old female and male mice, as observed by µCT. Average ± S.E.M at indicated time points for bone volume fraction (BV/TV) for female c and male d mice. Scatterplots from histomorphometry analyses of L3 vertebrae including number of osteoblast per bone surface (N.Ob/BS; e), number of osteoclasts per bone surface (N.Oc/BS; f), osteoid surface per bone surface (OS/BS; g), and mineralized surface per bone surface (MS/BS; h). F, Female; M, Male. Asterisks indicate a significant difference, *P < 0.05.