Table 1.

Histomorphometry values from L3 vertebrae of wild-type (Lgals3^+/+), heterozygous (Lgals3^KO/+), and mutant (Lgals3^KO/KO) mice at 24 wk^a

	Females			Males
Variables compared	Wild type	Heterozygote	Mutant	Wild type	Heterozygote	Mutant
OV/BV	0.06 ± 0.01	0.06 ± 0.01	0.07 ± 0.01	0.04 ± 0.01	0.05 ± 0.01	0.06 ± 0.01
OS/BS	0.43 ± 0.03	0.47 ± 0.06	0.54 ± 0.02	0.29 ± 0.02	0.30 ± 0.05	0.40 ± 0.05
O.Wi/μm	2.93 ± 0.14	3.08 ± 0.17	3.11 ± 0.13	2.80 ± 0.08	2.91 ± 0.20	2.58 ± 0.12
(N.Ob/BS)/mm-1	48.22 ± 4.52	54.52 ± 9.43	71.66 ± 2.87*	43.61 ± 4.15	40.55 ± 7.82	54.06 ± 5.01
(N.Oc/BS)/mm-1	10.70 ± 1.42	9.20 ± 0.98	9.42 ± 1.93	9.64 ± 1.56	8.04 ± 1.44	8.36 ± 1.85
Oc.S/BS	0.29 ± 0.03	0.26 ± 0.04	0.25 ± 0.04	0.20 ± 0.03	0.17 ± 0.03	0.24 ± 0.04
MS/BS	0.42 ± 0.04	0.46 ± 0.04	0.41 ± 0.06	0.37 ± 0.01	0.36 ± 0.02	0.42 ± 0.02
MS/OS	1.03 ± 0.17	1.00 ± 0.16	0.79 ± 0.09	1.35 ± 0.13	1.47 ± 0.22	1.12 ± 0.12
MAR/(μm·d-1)	1.01 ± 0.07	1.16 ± 0.13	1.06 ± 0.07	0.72 ± 0.03	0.79 ± 0.04	0.77 ± 0.03
Aj.AR/(μm·d-1)	1.06 ± 0.19	1.12 ± 0.16	0.82 ± 0.09	0.98 ± 0.10	1.13 ± 0.13	0.86 ± 0.12
(BFR/BS)/(μm3·μm-2 per day)	0.43 ± 0.05	0.52 ± 0.05	0.42 ± 0.05	0.25 ± 0.02	0.28 ± 0.02	0.32 ± 0.02
(BFR/BV)/% per day	16.61 ± 1.95	19.16 ± 1.57	15.64 ± 2.05	11.28 ± 1.15	12.94 ± 0.54	14.36 ± 1.01
Omt/d	2.97 ± 0.24	2.75 ± 0.29	3.02 ± 0.25	4.01 ± 0.16	3.58 ± 0.25	3.47 ± 0.31
Mlt/d	3.09 ± 0.62	2.91 ± 0.69	2.40 ± 0.35	5.34 ± 0.42	5.21 ± 0.81	3.80 ± 0.37

OV, osteoid volume; BV, bone volume; BS, bone surface; OS, osteoid surface; O.Wi, osteoid width; N.Ob, number of osteoblasts; N.Oc, number of osteoclasts; Oc.S, osteoclast surface; MS, mineralizing surface; MAR, mineral apposition rate; Aj.AR, osteoid adjusted apposition rate; BFR, bone formation rate; Omt, osteoid maturation time; Mlt, mineralization lag time.

^aValues are expressed as mean ± S.E.M. (n = 6–9). Holm–Sidak post hoc analysis adjusted P-values compared to wild type; bold values highlight *P < 0.05.