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. 2019 Mar 13;10:1193. doi: 10.1038/s41467-019-09114-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Blocking Aβ with anti-β-amyloid antibody 6E10 rescues the presynaptic deficit in hippocampal slices from 6–7-month-old APP/PS1 mice. a, b Representative traces (a) of mEPSCs in CA1 pyramidal neurons and quantification (b) of mEPSC amplitude (left) and frequency (right) in hippocampal slices from WT and APP/PS1 mice incubated in control (Ctrl) ACSF or ACSF containing 6E10. Two-way ANOVA with post hoc Bonferroni test; left panel: animal, F_(1,31) = 0.286, P = 0.597; treatment, F_(1,31) = 0.0119, P = 0.914; right panel: animal, F_(1,31) = 18.66, P < 0.001; treatment, F_(1,31) = 4.64, P = 0.039; *P < 0.05; ***P < 0.001; ^###P < 0.001 (APP/PS1 vs. WT); N = 8–10 per group. c, d Representative traces of SC-CA1 EPSCs evoked by stimulus intensities of 20, 40, and 100 μA (c) and quantification of EPSC amplitude to stimulus intensity (d) in hippocampal slices from WT and APP/PS1 mice incubated in Ctrl ACSF or ACSF containing 6E10. Two-way ANOVA with post hoc Bonferroni test; animal, F_(3,341) = 19.694, P < 0.001; treatment, F_(10,341) = 32.140, P < 0.001; ***P < 0.001 (compared with APP/PS1 + Ctrl group); N = 7–10 per group. e, f Representative traces (e) and quantification (f) of PPF of SC-CA1 EPSCs in hippocampal slices from WT and APP/PS1 mice incubated in Ctrl ACSF or ACSF containing 6E10. Two-way ANOVA with post hoc Bonferroni test; animal, F_(1,43) = 4.069, P = 0.049; treatment, F_(1,43) = 7.219, P = 0.01; *P < 0.05; **P < 0.01; ^#P < 0.05 (APP/PS1 vs. WT); N = 10–13 per group. Source data are provided as a Source Data file