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. 2019 Mar 13;10:1193. doi: 10.1038/s41467-019-09114-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Blocking mGluR5 with MTEP or selectively knocking out Efr3a in the CA3 area ameliorates oligomeric Aβ-induced impairment of a presynaptically-expressed LTP at the SC-CA1 synapse. a Representative traces showing averaged fEPSPs recorded in CA1 area 10 min before and 50 min after high-frequency SC stimulation (superimposed) in WT slices treated with vehicle (WT + Veh), oligomeric Aβ (WT + Aβ), MTEP (WT + MTEP), or both MTEP and oligomeric Aβ (WT + MTEP + Aβ), or in oligomeric Aβ-treated hippocampal slices from mice selectively knocking out Efr3a in the CA1 (CA1-Efr3a cKO + Aβ) or CA3 (CA3-Efr3a cKO + Aβ) area. b The time course of the normalized amplitude of fEPSPs before and after an LTP induction protocol in conditions shown in a. c Bar graph representing mean LTP magnitude 50 min after LTP induction shown in b. One-way ANOVA with post hoc Dunnett’s test; F_(5,48) = 5.171; *P < 0.05; **P < 0.01; N = 7–11 per group. d Representative traces of PPF of fEPSPs recorded in the CA1 area 10 min before and 50 min after high-frequency SC stimulation in the same conditions as in a. e The time course of the normalized PPF ratio before and after an LTP induction in the same conditions as in d. f Bar graph showing the relative PPF ratio before and after an LTP protocol. One-way ANOVA with post hoc Dunnett’s test; F_(5,25) = 6.361; **P < 0.01; N = 4–6 per groups. Data are mean ± SEM. Source data are provided as a Source Data file