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. 2019 Mar 13;9:4303. doi: 10.1038/s41598-019-40686-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the normalized signal intensity of lipids in urine that were identified as biomarker candidates for discriminating (a) meloxicam-treated (M) (n = 6) and saline-treated (C) cats (n = 6); and (b) baseline (BM) and meloxicam group (M) at different times after the administration of saline or meloxicam at 0.3 mg/kg every 24 h for up to 17 days (times 2 to 5). The lines in the boxes represent the median intensity value for each lipid; the upper and lower boundaries of the box indicate the 75th and 25th percentiles, respectively; the upper and lower whiskers represent the maximum and minimum values. The horizontal lines in the ROC boxes indicate the highest sensitivity and specificity in separating between control and meloxicam animals. *p < 0.05 and **p < 0.001.