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. 2019 Mar 13;9:4402. doi: 10.1038/s41598-019-39729-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of thapsigargin on contractions after TTX, L-NNA or ODQ. (A) Representative trace showing the effects of thapsigargin (1–10 μM) on the contractions of proximal colon after TTX (1 μM). (B) Representative trace showing the effects of thapsigargin (1–10 μM) on the contractions of proximal colon after L-NNA (100 μM). (C) Representative trace showing the effects of thapsigargin (1–10 μM) on the contractions of proximal colon after ODQ (10 μM). (D) Summarized data showing the effects of thapsigargin (1–10 μM) on contractions after TTX (1 μM; n = 15). (E) Summarized data showing the effects of thapsigargin (1–10 μM) on contractions after L-NNA (100 μM; n = 14). (F) Summarized data showing the effects of thapsigargin (1–10 μM) on contractions after ODQ (10 μM; n = 13). ^####P < 0.0001 compared to control, ns = P > 0.05 compared to TTX, *P < 0.05 compared to TTX, **P < 0.01 compared to TTX, ****P < 0.0001 compared to TTX.