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. 2019 Mar 13;9:4402. doi: 10.1038/s41598-019-39729-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of TTX, L-NNA and ODQ on Ca²⁺ transients in colonic ICC. (A) Representative STMs of spontaneous Ca²⁺ transients in colonic intramuscular ICC (ICC-IM) recorded in situ with a 60x objective in control (i) and in the presence of TTX (1 μM; ii), these maps are also displayed in 3-D format (iii–iv). (B) Representative STMs of spontaneous Ca²⁺ transients in ICC-IM recorded in situ in control (i) and in the presence of L-NNA (100 μM; ii). (C) Representative STMs of spontaneous Ca²⁺ transients in ICC-IM recorded in situ in control (i) and in the presence of ODQ (10 μM; ii). (D–F) Summarized data for the effects of TTX (n = 22), L-NNA (n = 19) and ODQ (n = 8) on spontaneous Ca²⁺ transient frequency in ICC. ****P < 0.0001 compared to control.