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. 2019 Mar 13;9:4398. doi: 10.1038/s41598-019-40942-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mean abundances of main autofluorescent components in superficial (red) and transitional (blue) layers of intact bovine articular cartilage (sample set 1–8). The bars represent the standard error from multiple samples (Supplementary Table S1). The extracted mean abundances of (a) collagen I, (b) collagen II, (c) unknown ECM component, UMC, (d) FAD, (e) NADH, (f) mean value of RR (FAD/NADH) and (g) total abundance of ECM obtained from hyperspectral imaging, calculated here as the sum of abundances of collagen I, collagen II and the fifth undefined fluorophore, likely to be also collagen or aggrecans. All values are calculated from mean abundances of extracted fluorophores. (h,i) Forward (first column) and backward scattered (middle column) SHG images for (h) superficial (upper row) and (i) transitional layers (bottom row) and the overlayed SHG images (third column). (j) Normalized mean abundance of total ECM in the superficial (red) and transitional layers (blue) derived from the SHG signal.