Figure 1.

Quantitative proteomic analysis of LPS-mediated moDC maturation over a 24 h period. (A–C) Volcano plots of all quantified proteins displaying differences in relative abundance at 6 h vs 0 h, 24 h vs 0 h and 24 h vs 6 h, respectively. The plot represents the -log₁₀ of the p-value against the log₂ of the fold change (FC). The green dots represent proteins with p-value ≤ 0.05 and log₂ fold-change > 0.5. Red dots represent proteins with q-value ≤ 0.2 and log₂ fold-change >0.5. D. Heat map representing the z-score derived from the log₂ relative abundance of the total 243 proteins that were significantly up or down-regulated (p-value ≤ 0.05) by >1.5-fold between any two of the three time points (0 h, 6 h or 24 h) examined.