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. 2019 Mar 13;9:4367. doi: 10.1038/s41598-019-39589-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of black raspberry extract (BRB), protocatechuic acid (PCA), ellagic acid (EA), and cabazitaxel (CBZ) on microtubule assembly in vitro. Tubulin polymerization was measured by fluorescence intensity at 60 minutes of exposure to 10–1,000 μg/mL black raspberry extract (A), 10 μg/mL protocatechuic acid (C), and 10 μM ellagic acid and 100 nM cabazitaxel (E), or combinations of 100 nM cabazitaxel with 1 mg/mL black raspberry extract (B), 10 μg/mL protocatechuic acid (D), and 10 μM ellagic acid (F). Data are mean values ± SD of 3–7 repeat measurements at 1 minute intervals.