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. 2019 Mar 13;9:4367. doi: 10.1038/s41598-019-39589-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combination effects of black raspberry extract (A) or ellagic acid (B) and CBZ on tubulin polymerization in 22Rv1 cells. Microtubules (green) were visualized by confocal microscopy with images enhanced for brightness and contrast. Binding affinity of docetaxel (C) and ellagic acid (D) for tubulin. This was determined by surface plasmon resonance and response-concentration plots are shown.