TABLE 1.
Subject recruitment
| Subjecta | Mesalamine formulationb |
Age (yr) | BMI | Sex | No. of samples from: |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stomach | Duodenum | Jejunum |
Stool | Total | |||||||
| Proximal | Mid | Distal | |||||||||
| M046-A | Pentasa | 38 | 21.2 | M | 1 | 8 | 7 | 1 | 17 | ||
| M046-B | Apriso | 38 | 21.3 | M | 8 | 5 | 6 | 19 | |||
| M046-C | Lialda | 38 | 21.7 | M | 8 | 6 | 7 | 1 | 22 | ||
| M047 | Pentasa | 36 | 21.1 | M | 8 | 6 | 14 | ||||
| M048 | Apriso | 51 | 34.3 | F | 5 | 7 | 12 | ||||
| M053 | Apriso | 34 | 25.2 | F | 1 | 7 | 3 | 11 | |||
| M061 | Pentasa | 51 | 21.6 | M | 7 | 8 | 15 | ||||
| M062 | Pentasa | 37 | 27.3 | M | 7 | 7 | 1 | 15 | |||
| M063 | Lialda | 26 | 28.6 | M | 7 | 5 | 5 | 17 | |||
| M064 | Lialda | 25 | 27.5 | F | 8 | 7 | 15 | ||||
| Summary | 40% Pentasa, 30% Apriso, 30% Lialda |
37 ± 8.6 | 25 ± 4.4 | 70% M | 44 | 64 | 13 | 27 | 6 | 3 | 157 |
a
Shown are selected metadata and sample collection demographics for 10 admissions. Subject M046 was admitted for three visits: A, B, and C. All subjects identified as Caucasian, and none identified as Hispanic/Latinx.
b
Pentasa has immediate release in stomach acid, Apriso has extended release at a pH of >6, and Lialda has extended release at a pH of >7.