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. 2019 Mar 13;9:4337. doi: 10.1038/s41598-019-40663-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Deletion of hematopoietic Dectin-2 or CARD9 does not influence cytokine secretion. At the end of the study, after 10 weeks of Western-type diet feeding bone marrow-derived macrophages (BMDMs, A–D) and peritoneal cells (E–H) from Ldlr^−/− mice transplanted with BM from control (WT), Dectin-2^−/− or Card9^−/− were isolated and ex vivo stimulated. (A) Tumor necrosis factor (TNF)α and (B) Interleukin (IL-)6 cytokine secretion were measured after stimulation with (A,B) lipopolysaccharide (LPS-EB, 10 ng/mL) or (C,D) Pam3Cys (10 µg/mL) in BMDMs. Similarly, (E,G) TNFα and (F,H) IL-6 were measured after stimulation with (E,F) LPS-EB or (G,H) Pam3Cys. Data are presented as mean ± SEM. n = 8/group. N.D., values are below detection limit. Detection limit is indicated with the black dotted line.