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. 2019 Mar 13;9:4373. doi: 10.1038/s41598-019-40760-x

Figure 5.

Figure 5

HMBA inhibits NK cell-mediated killing of leukemia T cells. (A,B) NK cells either treated with HMBA (EHMBA) or not treated (Ent) were used as effectors at various E:T ratio in a 4 h cytotoxicity assay against Jurkat, CEM and MOLT-4 target cells that have been as well exposed (THMBA) or not to HMBA (Tnt). (A) The percent specific lysis of a representative experiment out of 3 is shown. Results obtained with untreated NK cells (Ent) pre-incubated with saturating amounts of anti-NKG2D blocking mAb (α-NKG2D) and tested against Tnt are also shown. (B) Data are expressed as specific lysis inhibition at E:T ratio of 1:1 relative to Ent:Tnt lysis set at 100% (mean ± SEM, n = 3).