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kcat/Km (nm−1 s−1) of the μPlg activation by uPA
| uPA | Mammalian P3 |
Non-mammalian P3 |
||
|---|---|---|---|---|
| hμPlg WT | zfμPlg F(P3)P | hμPlg P(P3)F | zfμPlg WT | |
| huPA WT | 344.0 ± 80.0 (3) | 5.0 ± 1.1 (3) | 24.0 ± 5.0 (3) | 1.5 ± 0.2 (3) |
| huPA L97bG/R217E | 4.0 ± 0.3 (3) | 0.3 ± 0.09 (3) | 253.0 ± 9.0 (3) | 0.09 ± 0.03 (3) |
| zfuPAb WT | 1.2 ± 0.3 (3) | 25.9 ± 3.7 (3) | 16.0 ± 3.0 (3) | 468.0 ± 15.0 (3) |
| zfuPAb G97bL/E217R | 0.3 ± 0.02 (3) | 0.3 ± 0.1 (3) | NDa | 0.02 ± 0.02 (3) |
a ND, reaction rate too slow to be determined in this setup.
