Figure 2.

The E-resistant E. coli mraY alleles mapped on Aquifex aeolicus MraY_AA. The E. coli mraY alleles resistant to E are mapped on the structure of MraY from Aquifex aeolicus (MraY_AA) (PDB code 4J72). The structure is shown from the face that forms the putative E–MraY interface, and the domains of the interface are colored as follows: the periplasmic beta hairpin (yellow), the loop connecting PB with TMD5 (purple), TMD5 (magenta), and TMD9 (9a and 9b) (gray). The homologous E-resistant residues in MraY_AA are shown as spheres, and the catalytically important aspartate (red) and histidine (blue) residues are shown as stick projections.