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CLR01 inhibits SOD1 aggregation in vitro. A–E, aggregation kinetics was measured using the ThT fluorescence assay. WT SOD1 (A) or the variants E21K (B), H46R (C), D76Y (D), and G93A (E) were each incubated at 40 μm in the absence or presence of 40 or 200 μm CLR01. F–T, the morphology of the protein was examined at the end of each aggregation reaction by EM. Scale bars, 0.1 μm.
