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CLR01 partially disrupts the cross-β-structure in pre-formed SOD1 aggregates. Forty μm WT SOD1 or G93A-SOD1 were aged for 6 months and then incubated with 400 μm CLR01 in the presence of ThT, and the fluorescence was monitored every day for 26 days. Aliquots were taken in the beginning of the reaction (day 0), after 11 days, and at the end of the reaction (day 26) and examined by EM.
