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. 2018 Dec 31;294(10):3720–3734. doi: 10.1074/jbc.RA118.006848

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© 2019 Patil et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — Nuclear localization and PPAR activation for FABP1 mutants in the presence of GW7647. Each panel depicts the individual data points for the experiment as well as mean and standard deviation. A, quantification of ligand-induced changes in nuclear localization (nuclear to cytosolic ratio) of GFP-FABP1 and the K20A/K31A double mutant using high-content imaging. B, transcriptional activity of PPARα is enhanced by the presence of FABP1 and the K20A/K31A double mutant upon treatment of PPARα-expressing COS-7 cells with either GW7647 or oleic acid. C, quantification of ligand-induced changes in the nuclear localization (nuclear to cytosolic ratio) of GFP-FABP1 and the K57A/E77A/K96A triple mutant using high-content imaging. D, transcriptional activity of PPARα is enhanced by the presence of FABP1 but not the K57A/E77A/K96A triple mutant upon treatment of PPARα-expressing COS-7 cells with either GW7647 or oleic acid. ***, p < 0.001 versus vehicle (B) or vector (C) control, two-way ANOVA with Dunnett's multiple comparisons test.