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. 2019 Jan 11;294(10):3603–3617. doi: 10.1074/jbc.RA118.006123

Figure 2.

Figure 2.

PO-induced up-regulation of YAP was inhibited in YAP-CHKO mice. TAC or sham operation was applied to WT or YAP-CHKO mice for 7 days. A and B, whole-heart lysates were subjected to immunoblotting with anti-YAP antibody. GAPDH antibody was used as loading control. Data are expressed as a ratio compared with the mean value of the WT-sham group. n = 6 per group. C and D, total RNA was extracted from the heart and subjected to quantitative RT-PCR analyses. Relative mRNA expression of Ctgf (C) and Ankrd (D) is shown. n = 5–6. The data are expressed as ratios relative to the mean value of the WT-sham group. Data in graphs represent mean ± S.D.; **, p < 0.01; ***, p < 0.005 compared with Shams; $, p < 0.05 in comparison with WT-sham and YAP-CHKO-Sham; #, p < 0.05; ##, p < 0.01, in comparison with WT-TAC and YAP-CHKO-TAC. Statistical analyses were conducted with ANOVA. Post hoc analysis was conducted with Tukey's test.