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. 2019 Jan 11;294(10):3603–3617. doi: 10.1074/jbc.RA118.006123

Figure 4.

Figure 4.

TAC-induced cardiac dysfunction was exacerbated in YAP-CHKO mice. WT and YAP-CHKO mice were subjected to either TAC or sham operation for 7 days. Echocardiography and hemodynamic analyses were performed before euthanasia 7 days after TAC or sham operation. A, representative images of M mode echocardiography. B, % fractional shortening. C, left ventricular end-diastolic diameter (LVEDd, mm). D, wall stress calculated using the data set obtained by echocardiography and hemodynamic measurement. E, left ventricular end-diastolic pressure (LVEDP, mm Hg) evaluated with a Millar catheter. n = 12–14 per group. B–E, values are mean ± S.D. **, p < 0.01; ***, p < 0.001 versus shams; #, p < 0.05 in comparison with WT-TAC and YAP-CHKO-TAC. Values are means ± S.D. Statistical analyses were conducted with ANOVA. Post hoc analysis was conducted with Tukey's test.